Dr. Soonjo Hwang (University of Nebraska Medical Center) joins AJP Audio to discuss the response to intranasally-administered oxytocin in youths with severe irritability. 00:56     Hwang interview 02:09     Effects of oxytocin 05:45     Intranasal oxytocin 07:04     Potential adverse effects of oxytocin 08:08     Imaging 08:58     Preliminary investigations and clinical implications 09:51     Limitations 10:14     Further research 11:00     Kalin interview 11:33     Hwang et al. 14:43    ...

Dr. Drew Rothenberg (Duke University, Durham, NC) joins AJP Audio to discuss the long term, intergenerational impacts of the Fast Track program, and whether the mental health intervention lead to lasting improvements in mental health, including in the participants own children.   00:49     Rothenberg interview 04:36     A null result? 07:13     At risk children from high risk neighborhoods 08:00     Limitations 09:17     Demand for childhood mental health services and clinical...

Dr. Ofir Livne (Columbia University, New York) joins AJP Audio to discuss recent trends in the prevalence of cannabis use disorder in US veterans with and without psychiatric disorder diagnosis.  Dr. Ned Kalin joins afterwards to discuss how the rest of the February issue of AJP touches on cannabis use disorder and other substance use disorders. 00:31     Livne interview 03:16     Changes in the legal landscape surrounding cannabis use 05:17     The complex association between cannabis...

Dr. Jaclyn Ross, Ms. Jordan Barone, and Dr. Tory Eisenlohr-Moul (University of Illinois at Chicago) join AJP Audio to discuss the impact of the menstrual cycle on suicide ideation and planning in psychiatric patients with suicidality. Afterwards, American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin brings us up to date on the rest of the January issue of AJP. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts,...

Dr. Aaron Samuel Breslow (Montefiore Medical Center and Albert Einstein College of Medicine) joins AJP Audio to discuss the racial and ethnic disparities in the impact of COVID-19 and pandemic related stressors and adverse mental health outcomes on health care workers in the Bronx, New York.  Following we’ll once again check in with American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin on the rest of the December issue of AJP. Breslow interview [00:56] Why look at the Bronx in...

Dr. Winston Chung (Kaiser Permanente Northern California) joins AJP Audio to discuss inequalities in the diagnosis of psychotic disorders between racial and ethnic groups in a large cohort. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the November issue of AJP, which focuses on different aspects of psychotic disorder. Chung interview [00:30] Structural racism and missing socioeconomic strata [02:58] ...

Dr. Luis Farhat and Dr. Guilherme V. Polanczyk (University of São Paulo, Brazil) join AJP Audio to discuss the impact of socioenviromental factors, emotional dysregulation, and other factors impact neurodevelopment in children. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the September issue of AJP and what brings it together. Farhat and Polanczyk interview [00:54] Comorbidities and associations [03:22] ...

Dr. Antony Chum (York University, Toronto) joins AJP Audio to discuss disparities in suicide-related behaviors between sexual orientations by gender in a large cohort from the province of Ontario. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the September issue of AJP and what brings it together. Transcript Chum interview [00:34] Results [02:14] Using a large data set [03:21] Correcting the limitations...

Dr. Lucy S. King (Tulane University School of Medicine, New Orleans) and Dr. Kathryn L. Humphreys (Vanderbilt University, Nashville) join AJP Audio to discuss the long term impacts of a pioneering randomized controlled trial that looked at the impacts of institutional care versus home foster care in children, the Bucharest Early Intervention Project.  They also discuss the impacts of deprivation on children’s development and mental health, and the thorny ethics of research involving...

Dr. Dylan J. Jester (VA Palo Alto Medical Center in Palo Alto, California) joins AJP Audio to discuss the differential impact of selected social determinants of health on the mental health outcomes of older Black, White, and Latinx adults in the United States. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses how issues of substance use disorder draw together the rest of the July issue. Transcript Jester interview [00:48] Which social determinants of health did you focus on?...

Dr. Mark Olfson (Columbia University) discusses the links between opioid prescribing and suicide risk in the United States. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses how issues of substance use disorder draw together the rest of the June issue. Transcript Olfson interview [00:46] Geographic commuting areas [01:06] Opioid prescription measures [02:10] Rates of opioid prescription and suicide [03:27] Youngest age cohorts as outliers [04:19] Regional variations [04:57] ...

Ms. Gal Arad (Tel Aviv University, Tel Aviv, Israel) discusses a non-pharmacological intervention for the treatment of social anxiety disorder in comparison with standard care.  Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the May issue. Transcript Arad interview [00:18] What were your results? [02:11] Reduction in dwell time on threatening faces [03:36] Limitations [04:09] Immediate clinical implications [05:27] Further...

Dr. David G. Amaral (University of California, Davis) is an author of a review paper in the April issue of AJP looking at the use of animal models and other forms of translational neuroscience in the investigation of autism spectrum disorder.  He joins us on AJP Audio to discuss it.  Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the April issue.  Transcript   Amaral interview [00:56] Advantages and disadvantages of animal model...

Dr. Gary S. Sachs (Harvard Medical School) joins us for the for the March episode of AJP Audio, discussing the results from a phase 3 study looking at the use of atypical antipsychotic cariprazine as an adjunctive treatment for major depression in conjunction with antidepressants.  Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the March issue. Transcript Sachs interview [00:47] Why is treating major depressive disorder in patients...

This episode of AJP Audio features two articles from the February issue of AJP.  First up, we have Nathaniel G. Harnett, Ph.D. (Harvard Medical School), discussing the impact of adversity and stress on racial disparities in childhood brain development among Black and White American children.  Following that, Ziv Ben-Zion, Ph.D. (Yale University), discusses a non-exact replication study of a study published in AJP by Stevens et al. (previously featured on AJP Audio) looking at brain-based...

Dr. Stefanie Russman Block (University of Michigan, Ann Arbor) discusses a trial looking at whether connectivity patterns in the brain can be used to predict treatment response in patients with obsessive-compulsive disorder.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses childhood and neurodeveloment-related psychiatric disorders explored in the January issue. Russman Block interview [00:51] Exposure and response prevention versus stress management therapy [05:46] Investigating...

Dr. Rebecca Price (University of Pittsburgh) discusses a novel, computer-based intervention designed to extend the antidepressant effects of a single dose of ketamine. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue and what draws it together. Price interview [00:40] What does the computer-based intervention consist of? [03:55] Comparator arms [05:25] Are there immediate clinical implications? [08:04] Limitations [10:19] Further research [12:17] Kalin...

Dr. Antonia Seligowski (McLean Hospital and Harvard Medical School) discusses how significant genetic correlations were identified between PTSD and cardiovascular disease as well as support for a causal link from PTSD to hypertension and coronary artery disease.  Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue and what draws it together. Seligowski interview [00:50] Genome-wide association studies [02:24] The Mass General Brigham Biobank [03:05] What...

Dr. Richard Davidson (University of Wisconsin-Madison) discusses the effects of mindfulness training on the neural mechanisms of pain and what it means for the future of pain management. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses what draws together that paper and the rest of the October issue. Davidson interview [00:37] How do you go about investigating pain? [05:41] Lack of apparent difference in neural response among long-term meditators [06:45] What does this mean for pain...

Dr. Lauren A. M. Lebois (Dissociative Disorders and Trauma Research Program, McLean Hospital, Harvard Medical School) discusses persistent dissociation following trauma exposure and whether it can be predictive of later psychiatric outcomes in at risk populations. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the September issue and what draws it together. Lebois interview [00:52] A prototypical adult dissociation case [01:51] Dissociation as a rollercoaster [05:48]...

Dr. Mark D. Shen (University of North Carolina, Chapel Hill) discusses the trajectory of brain development in infants at risk for autism spectrum disorder (ASD) and fragile X syndrome.  Longitudinal imaging was captured from 6 to 24 months to see how brain development differed between groups, and the development of the amygdala in infants at risk for ASD prior to onset of social deficits and clinical diagnosis. Shen interview [01:03] Why look at patients with potential ASD diagnosis in...

Dr. Richard S.E. Keefe (Duke University Medical Center, Durham, North Carolina) discusses an article looking at an intervention for major depressive disorder that takes the form of a videogame. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the July issue’s theme. Keefe interview: [01:00] What were your results? [03:13] What do videogames offer as a depression intervention? [03:43] Differences between the intervention and the control intervention [05:05] What was the impact of the...

AJP Editor-in-Chief Dr. Ned Kalin discusses the June issue with guest editor Dr. Crystal Barksdale (National Institute on Minority Health and Health Disparities). The issue focuses on mental health disparities, the pervasive negative consequences of structural racism, and the importance of community-wide and systemic interventions. Barksdale interview [00:30] How do mental health disparities differ for minoritized groups? [04:10] Structural and institutional racism as a factor in mental...

Dr. Kenneth Kendler (Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University, Roanoke, VA) discusses the history and emergence of psychiatry as a discipline, and how the conception of mind, body, and soul evolved. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses the May issue of AJP, and the past, present, and future of psychiatry. Kendler interview [00:45] Why is it important to look at the history of psychiatry? [10:28] The emergence of...