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钰沐菡_漫谈医药
Biotech Bar
以轻松愉快的方式聊聊AI制药
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Ratings & Reviews
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4.2 stars from 18 ratings
Recent Episodes
小核酸药物在当前医药行业中非常火热，但在递送技术的创新层面依然存在困境，已上市的小核酸药物仅能针对肝脏靶点。小核酸抗体偶联药物（Antibody-oligonucleotide conjugates，AOC）和小核酸多肽偶联药物（Peptide-oligonucleotide...
Published 10/21/23
Published 10/21/23
"靶向分子+偶联药物”模式（XDC）由靶向分子、连接体 (linker)、效应分子（payload）组成，识别肿瘤细胞后内吞进入溶酶体后释放药物，通过诱导微管抑制、DNA损伤引起细胞凋亡，同时也通过旁观者效应杀死周围肿瘤细胞。
抗体偶连药物 （ADC）中使用的payload一般是细胞毒性化合物。目前最常用的payload主要针对DNA或微管蛋白，针对DNA的有：卡利霉素、双卡霉素、PBD、SN-38和DXd，针对微管蛋白的有 Auristatins（MMAE、MMAF）...
Published 10/09/23
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