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Muscle fibers are cylindrical cells that can contain hundreds of nuclei called myonuclei. On the periphery of these muscle fibers, stem cells, known as satellite cells, lay dormant in a quiescent state during resting conditions. With exercise, these cells can activate, often proliferate and may fuse to muscle fibers. Historically, this fusion of satellite cells has been thought to be to mediate the repair of focal damage to the muscle fiber. Additionally, it has been suggested that a myonucleus, which serves as a control center, can oversee only a finite jurisdiction – called the myonuclear domain. Therefore some researchers have speculated that satellite cells could supply additional nuclei to the muscle fiber during hypertrophy to keep up with the increasing domain. Interestingly, there is a recently growing body of evidence suggesting several non-fusion-related roles satellite cells can play. – Today, Dr. Kevin Murach is here to give us some insight into the interplay of satellite cells and muscle growth!

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Dr. Murach received a Ph.D. in Human Bioenergetics from Ball State University in 2015 and post-doctoral training in muscle stem cell biology at the University of Kentucky Center for Muscle Biology. His research broadly pertains to adult skeletal muscle mass regulation in the context of exercise, aging, and beyond. Currently, he is positioned as an Assistant Professor at the University of Arkansas and serves as the principal investigator/project leader in the Molecular Muscle Mass Regulation Laboratory. 



Kevin's Google Scholar: https://scholar.google.com/citations?user=45UuplEAAAAJ&hl=en



Kevin’s ResearchGate: https://www.researchgate.net/profile/Kevin-Murach



Kevin's Twitter: https://twitter.com/KevinMurachPhD



Kevin's Instagram: https://www.instagram.com/kevinmurachphd/

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This is the 32nd episode of the #coachingcues podcast! If you want to have your question answered by an expert, please head to www.coachingcues.org/ask


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Historically, strength training has been prescribed based on set configurations where continuous repetitions are performed followed by inter-set rest periods, ranging from 1 to 5 min in duration. These configurations are referred to in the literature as traditional sets. However, it is unclear if these set configurations provide an optimal or advantageous stimulus compared to other techniques. Consequently, implementing intra-set rest periods, collectively known as cluster sets, is suggested to provide a novel stimulus to optimize resistance training adaptations. But what is the evidence behind using cluster sets for strength and hypertrophy? - Dr. Timothy Davies is here to give us some insight!

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Timothy Davies, PhD, is a Lecturer of Exercise Science at Sydney University. His research interests are in the training methods, biomechanics and physiology behind improving strength, power and hypertrophy, particularly in strength athletes. Currently, his particular focus areas are related to proximity to failure, intended/actual movement velocity, volume and the effective repetitions paradigm.

Timothy's ResearchGate: https://www.researchgate.net/profile/Timothy-Davies

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Momentary failure can be defined as the point trainees reach where despite attempting to do so, they cannot complete the concentric portion of their current repetition without deviation from the prescribed form of the exercise. Instead of momentary "muscular" failure, the term momentary failure is used because there is no current consensus on where the lack of continued ability to carry on with the task despite attempts to do so arises. Confusing terminology, among other things, highlights the limitations of the current research on proximity to failure. - James Fisher, PhD, is here to give us some insight!

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James Fisher completed his BSc (Hons) in Sports Science from the University of Chester, his MSc in Exercise Physiology from Manchester Metropolitan University, and his PhD through Nottingham Trent University. Currently, he works as a senior lecturer at Solent University.



James's ResearchGate: https://www.researchgate.net/profile/James-Fisher-25

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This is the 30th episode of the #coachingcues podcast! If you want to have your question answered by an expert, please head to www.coachingcues.org/ask


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Proximity-to-failure can be defined as the number of repetitions remaining in a set before momentary muscular failure -meaning when an individual cannot complete the concentric portion of repetition with the prescribed range of motion without deviation from the given exercise technique. At the level of one set, as one approaches failure, muscle fiber activation and, thus, mechanical tension - the key stimulus for hypertrophy progressively increases. However, the addition of neuromuscular fatigue may change this relationship at the level of an entire training session. This begs the question, how should you manipulate proximity to failure on a session basis? - Martin Refalo is here to give us some insight!

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Martin Refalo is a Ph.D. Candidate at the School of Exercise and Nutrition Sciences at Deakin University. Currently, he's interested in the influence of proximity-to-failure for muscle hypertrophy in resistance training.

Martin's ResearchGate: https://www.researchgate.net/profile/Martin-Refalo-2

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This is the 29th episode of the weekly #coachingcues podcast! If you want to have your question answered by an expert, please head to www.coachingcues.org/ask


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Before major competitions - whether regional, national, or world championships or just you maxing out at the gym - lifters use tapering to achieve peak performance on a given day. Unfortunately, most tapering literature has focused on endurance sports, and the current literature on tapering and peaking maximal strength is scarce. Luckily, a group of researchers has taken it upon themselves to fill the literature gap; thus, one of them, Dr. Kyle Travis, is here to provide us with some insight! 

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Dr. Kyle Travis is a Postdoctoral Research Scientist at the University of Florida. His current research foci consist of skeletal muscle biology, atrophy prevention, aging, neuromuscular junction morphology, gene expression, and gene manipulation.



Kyle's ResearchGate: https://www.researchgate.net/profile/Kyle-Travis

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This is the 28th episode of the weekly #coachingcues podcast! If you want to have your question answered by an expert, please head to www.coachingcues.org/ask


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In the final days of competition preparation, bodybuilders usually implement interventions to "peak" their body to maximize contest day aesthetics. These interventions aim to 3) maximize muscle glycogen content to enhance muscle "fullness," 2) minimize subcutaneous water to look dry, and 3) minimize abdominal bloating to maintain a small waistline. But how may one accomplish all these? - Dr. Andrew Chappell provides us with some insight!

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Dr. Andrew Chappell is a Lecturer/Researcher at Robert Gordon University School of Pharmacy and Life Science. His interests are primarily in sports nutrition, with a specific focus on bodybuilding.



Andrew's ResearchGate: https://www.researchgate.net/profile/Andrew-Chappell



Papers mentioned:

https://www.mdpi.com/2075-4663/6/4/126

https://bmcsportsscimedrehabil.biomedcentral.com/articles/10.1186/s13102-021-00296-y

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This is the 27th episode of the weekly #coachingcues podcast! If you want to have your question answered by an expert, please head to www.coachingcues.org/ask


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