In view of the current political climate, this edition of CTBTO Spectrum focuses on the role of the Comprehensive Nuclear-Test-Ban Treaty (CTBT) in the wider non-proliferation and disarmament context. We are privileged to have received articles from several internationally acclaimed leaders and political figures including President Oscar Arias of Costa Rica, IAEA Director General Mohamed ElBaradei, former US Senator Sam Nunn, and US senior diplomats, Ambassadors Max Kampelman and Tom Graham. Their contributions are complemented by an article by Daryl Kimball, Executive Director of the Arms Control Association, and there are also feature articles on the Integrated Field Exercise 2008 for on-site inspections, the challenges of establishing monitoring stations in Antarctica, the ongoing International Scientific Studies project to assess the readiness and capability of the CTBT to detect nuclear explosions worldwide, and the cooperation between the CTBTO and the World Meteorological Organization.