Mayim and Brian discuss their life experiences and dissect Brian’s transformation from "nerd" to famous comedian and the impact of being a big man. Brian recounts his time working with Mayim on the Big Bang Theory and his excitement playing Dungeons and Dragons with Mayim and other members of the team! Mayim examines recent scientific research on the therapeutic potential of this socially engaging tabletop game! The conversation leads into a discussion of coping mechanisms and subsequent discussion of Brian’s use of marijuana. Both Brian and Mayim examine the risks and benefits of marijuana use.