Medizin - Open Access LMU - Teil 08/22 Ludwig-Maximilians-Universität München

The authors report their experience with the autogenous microsurgical
lymphvessel transplantation for the treatment of upper
(n = 60, 55 females and 5 males) and lower (n = 35, 10 females
and 25 males, primary lyphredemas = 11, secondary lymphredemas
= 24) limb edemas.
Regarding the volume measurements before and after lymphvessel
- transplantation in 58 patients there was a reduction of
volume differences between healthy and affected arms of more
than the half in 76 % of the patients after a mean follow-up
period of 2 1/2 years.
In 28 patients with unilateral redemas of the lower extremities
the volume reduction after a mean follow-up period of I 1/2
year compared to the healthy legs was more than 50 % in
20 patients.
As complications in the early period 2 postoperative erysipelas
were seen. One patient developed a Iymph cyst in the groin and
one patient had a postthrombotic lower leg rederna.
The authors conclude that lymphvessel transplantations therefore
seem to be a method to enhance significantly the lymphatic
transport if by conservation me ans alone no long term success
is seen.

Multifractionation isoeffect data are commonly analysed under the assumption that cell survival determines the observed tissue or tumour response, and that it follows a linear-quadratic dose dependence. The analysis is employed to derive the α/β ratios of the linear-quadratic dose dependence, and different methods have been developed for this purpose. A common method uses the so-called Fe plot. A more complex but also more rigorous method has been introduced by Lam et al. (1979). Their method, which is based on numerical optimization procedures, is generalized and somewhat simplified in the present study. Tumour-regrowth data are used to explain the nonparametric procedure which provides α/β ratios without the need to postulate analytical expressions for the relationship between cell survival and regrowth delay.

Current recordings from single chloride channels were obtained from excised and cell-attached patches of rat and human axons. In rat axons the channels showed an outwardly rectifying current-voltage relationship with a slope conductance of 33 pS at negative membrane potentials and 65 pS at positive potentials (symmetrical 150 mM CsCl). They were measurably for cations (PNa/PCs/PCl=0.1/0.2/1). Channel currents were independent of cytoplasmatic calcium concentration. Inactivation was not observed and gating was weakly voltage dependent. Cl− channels in human axons showed similar gating behavior but had a lower conductance.