Featuring articles on left atrial appendage occlusion during cardiac surgery, thrombosis after ChAdOx1 nCoV-19 vaccination, adjuvant nivolumab for invasive urothelial carcinoma, a meningococcal X vaccine in Mali, and irritable bowel syndrome and immunity; a review article on HIV infection; a Clinical Problem-Solving describing a hypertensive heartbreak; and Perspective articles on women’s health; on institutional problems, individual solutions; and on merging mortalities. Supplement to the New England Journal of Medicine, Vol. 384, No. 22.