Jeff and Spencer are father-and-son bandmates in Tweedy, and musical collaborators across other projects, too. Jeff is the lead singer and songwriter of the band Wilco, so music would have always been a part of their family’s life, but making music together has been the way the two of them have connected since Spencer was a very young kid. You can find their music at wilcoworld.net, and find them on Twitter at @jefftweedy and @spencertweedy.

Aminatou and Ann are the co-hosts of the podcast Call Your Girlfriend, co-authors of the book Big Friendship, and long-distance best friends. Their podcast made their friendship public, but behind the scenes, the geographic distance turned into emotional distance, and they had to find a way to re-connect. You can find their podcast at callyourgirlfriend.com, find their book at bigfriendship.com, and find them on Twitter and Instagram at @aminatou and @annfriedman.

Tegan & Sara have been bandmates for over 20 years. They’re also identical twin sisters. Having a twin is already a special kind of relationship—how does it work when your twin is also your creative collaborator and business partner? For their entire lives, Tegan and Sara have been learning how to co-exist in a way that’s inextricably linked but still allows them to define themselves as individuals. Learn more about their band at teganandsara.com, and follow them on Instagram and Twitter...

Daveed and Rafael are best friends and artists who have collaborated across film, theatre, music, and poetry. Because of that their partnership extends beyond the normal boundaries of friendship, and the normal boundaries of a working relationship. From their days as high school classmates, to barely scraping by as roommates in LA, to the triumph of seeing their film premiere at Sundance, the two of them have been there with each other—and for each other—for nearly two decades. You can find...

PJ & Alex are the co-hosts and co-creators of the hit podcast Reply All. Their story together begins over a decade ago, when they were both starting out in public radio. Across multiple shows, they’ve refined their skills as storytellers, and their ability to understand one another. Reply All listeners know how much they torture each other when they’re on the mic—but the two of them explain how that’s evidence of their partnership at its best. You can follow PJ and Alex on Twitter at...

Rachel & Aline are the co-creators of the Emmy- and Golden Globe-winning television show Crazy Ex-Girlfriend. Their show challenged the tropes of romantic comedies, but before the two of them subverted the meet-cute, they had a meet-cute of their own. It led to a creative partnership that’s been going for over six years. You can follow Rachel and Aline on Twitter, at @racheldoesstuff and @alinebmckenna.

Kevin & Mike are the co-founders of Instagram. What began with a chance meeting at a cafe turned into a billion dollar business and a partnership that’s lasted a decade. A key to their relationship was understanding each other’s strengths and how those translated into individual roles at a company: CEO and CTO, respectively. But the title that came first and foremost, for both of them, was co-founder. You can find Kevin and Mike on Instagram at @kevin and @mikeyk.

Samin & Wendy are the author and the illustrator of the award-winning cookbook Salt Fat Acid Heat. Their partnership began with an email that Samin sent to Wendy, out of the blue. Six years later, the book was published, and became a #1 New York Times Bestseller, and a hit show on Netflix. The two of them are already working on their next book. But like with any great recipe, their partnership isn’t just about the ingredients; it's about finding the right balance between them. Learn more...

Every successful partnership, no matter what kind, is sort of a love story. That’s what this new podcast is about. What did it take for two people to meet, and figure out how to make something together? Each episode is a portrait of two partners and the story they share.