The schedule is set! Ryan Wilson and John Breech team up to dissect all angles of the 2021 NFL slate. 2/3 of the Pick Six Superfriends examine notables like the season opener between the Cowboys and Bucs, Tom Brady's return game vs. the Patriots, and some big matchups for the Chiefs. The guys also cover the holiday slate and primetime schedule, evaluating the best matchups for Monday Night Football, Sunday Night Football and Thursday Night Football. What are the games you won't want to miss? The crew has you covered with this instant reaction. 'Pick Six' is available on Apple Podcasts, Spotify, Stitcher, Google Podcasts, Castbox and wherever else you listen to podcasts.  You can listen to Pick Six on your smart speakers! Simply say "Alexa, play the latest episode of the Pick Six NFL podcast" or "Hey Google, play the latest episode of the Pick Six NFL podcast." Follow the Pick Six team on Twitter: @picksixpod, @willbrinson, @ryanwilsonCBS, @johnbreech, @E_DeBerardinis Visit the Pick Six YouTube channel: https://www.youtube.com/picksix Check out the Pick Six Instagram page https://www.instagram.com/picksixpod/?hl=en Read the Pick Six newsletter here: https://www.cbssports.com/newsletters/picksix/ Join our Facebook group https://www.facebook.com/groups/758548147935545/ For more NFL coverage from CBS Sports, visit https://www.cbssports.com/nfl/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ Learn more about your ad choices. Visit megaphone.fm/adchoices