Episode #253. In Part Three of the blood lipids series, we take a deep dive into interventions to lower the risk of atherosclerotic cardiovascular disease (ASCVD). While nutrition is the most powerful lifestyle tool we have to dramatically decrease ApoB, there certainly remains a need for pharmacological interventions – and in this episode, Dr Thomas Dayspring and I walk through four main drug classes, discussing their mechanism of action, effectiveness, and safety profile. We discuss: Intro (00:00) Evolution of cardiovascular disease treatments (03:42) Are we becoming a drug-dependent society? (07:30) Bile acid sequestrants, statins, and more (13:54) Cholesterol-lowering drugs and cognition (35:12) Is Bempedoic acid a good statin alternative? (47:39) Ezetimibe and nuances you should know (55:46) PCSK9 inhibitors (1:03:32) Do statins increase the risk of diabetes? (1:14:58) Gene therapy targeting PCSK9 (1:19:20) Pelacarsen for lowering Lp(a) (1:23:48) Can we take drugs that raise HDL to lower cardiovascular disease risk? (1:26:38) HDL and atherosclerosis (1:34:59) Elevated triglycerides and atherosclerosis (1:46:48) Takeaways (2:05:12) Outro (2:08:31) The best place to connect with Dr Thomas Dayspring is on Twitter, @DrLipid. Learn more about Dr Dayspring’s career and current work on LinkedIn. Head to The Proof website for the full show notes, including supporting studies and my key takeaways. To assist with the digestibility of this content, Dr Dayspring, my team, and I have included extensive illustrations and graphs in the video format of these episodes. If you are visually inclined, you can watch these episodes on The Proof YouTube channel. Even if you prefer listening through audio the first time, I highly recommend coming back for a second pass with the video versions. These episodes are investments into a healthier future. We are also currently working on a summary PDF highlighting the key learnings from each part of the series. To receive a copy of this simply submit your email at theproof.com/lipidseries. We are also working on transcripts for these episodes, with the release date to be advised soon. Enjoy, friends. Simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary two-week meal plan and high-protein Plant Performance recipe book