Karen covers the topic of estrogen loss during perimenopause and its effects on skin health, particularly facial skin. She explores how declining estrogen levels lead to reduced skin elasticity, collagen loss, and increased dryness, and discusses the benefits of using topical estrogen creams to counteract these effects. She also reviews the history of estrogen in skincare, recent studies on its effectiveness, and shares her own experience with adding estrogen cream to her facial care regimen. Visit our website itchyandbitchy.com to read blog posts on the many topics we have covered on the show.