In this episode, Lindsay Pino discusses the challenges of making quantitative measurements in the field of proteomics. Specifically, she discusses the difficulties of comparing measurements across different samples, potentially acquired in different labs, as well as a method she has developed recently for calibrating these measurements without the need for expensive reagents. The discussion then turns more broadly to questions in genomics that can potentially be addressed using proteomic measurements. Links: Talus Bioscience Matrix-Matched Calibration Curves for Asssessing Analytical Figures of Merit in Quantitative Proteomics (Lindsay K. Pino, Brian C. Searle, Han-Yin Yang, Andrew N. Hoofnagle, William S. Noble, and Michael J. MacCross)