The Meta Health Podcast Ronesh Sinha, MD

I'm feeling an urge to shift my content in a new direction. I'm not giving up on discussing metabolism since that's a topic that is still very close to my heart, but at the age of 52 and after digging deep into insulin resistance for well over a decade, I'm sensing a different pull. 
In this episode I discuss my internal transformation and how you too might have a different voice inside that is longing for a new direction. 

This episode takes a fresh look at the 3 fundamental molecular root causes of insulin resistance using some familiar storylines from prior episodes combined with some new story hooks to help you understand the science of insulin resistance. We cover the following:
Quick review of insulin mechanism of action Summarizing the 3 root causes or what I call "-emias" of insulin resistance The inflammation-insulin resistance link explained using a busy ER analogy Using lifestyle changes to manage the 3 root causes

This episode digs deep into protein and more specifically amino acids (protein building blocks) and their role in metabolism, weight control, insulin resistance, and overall health. We cover some of the following:
Quick overview of mitochondrial metabolism Introducing protein and amino acids The role of amino acids in energy production Fasting and ketosis Can excess protein intake lead to fat/weight gain? The link between amino acids and insulin resistance  

I've selected 2 key metabolic ingredients, Acetyl CoA and Citrate, to explain nutrition metabolism in further detail. I've also selected a different storyline, the mitochondrial amusement park and the Kreb's merry-go-round, to help you visualize some of the most fundamental steps of metabolism. In this episode we cover:
Acetyl CoA's role as a key metabolic conductor The metabolic merry-go-round used to explain Kreb's cycle The importance of the Citrate sensor in switching between anabolism and catabolism How these concepts are tied to the root cause for weight gain and insulin resistance A critique of B-vitamin supplements as "energy producers"

The mental and metabolic impact of human beings predominantly or exclusively working from home has been profound. I've noticed significant increases in insulin resistant conditions including premature heart disease and a deterioration in mental health. All of these risks existed pre-pandemic, reflecting our modern digital lifestyles, but post-pandemic these risks have intensified to an even worse public health crisis. In this episode I cover some of the following:
Overall impact of WFH (work from home) on metabolic and emotional health Evidence-based guidelines for MED (minimum effective dose) of daily walking steps and strength training minutes per week MED for minutes of aerobic training with tips on improving adherence Digging into the science of ZEF (Zoom Exhaustion Fatigue) based on Stanford University research Impact of WFH on stress and sleep

I see lots of patients in my clinic who aim to lose body fat and have become well versed in the different types of body fat, specifically subcutaneous adipose tissue (aka SAT) and visceral adipose tissue (aka VAT). Although VAT and SAT are both fat, they represent different health risks and there are some differences in terms of which strategies are more effective for VAT vs SAT loss. This episode is a good follow-up to Episode 16 (Getting Your Body to Burn Fat), which provides the scientific foundation for fat loss (aka lipolysis) along with providing practical suggestions as well. In this episode, we cover:
Overview of SAT (subcutaneous fat) vs VAT (visceral fat) How to measure SAT vs VAT Dietary approaches to tackle SAT vs VAT Deep dive on which exercises and routines address SAT vs VAT Other lifestyle factors that address SAT and VAT