This episode of The Muscle Memoirs Podcast is a continuation of last week's installment with Lyle McDonald. In an attempt to provide a comprehensive answer to the aforementioned question, we cover other factors to consider such as frequency, per session volume, rest intervals, and more.  Timestamps 01:37 Training frequency for the advanced lifter 04:45 How many sets should be performed per workout? Is there a per-session volume limit? 26:48 How to count volume 29:57 Hypothetical: 8 sets to 1RIR or 16 sets to 3 RIR, is one superior for muscle hypertrophy in advanced lifters? 33:17 Effective reps model 39:57 Mechanical tension is king 45:07 Factoring fatigue into the per-session volume equation  51:07 Putting it all together: the relationship between per session volume, frequency, and proximity to failure 59:07 Taking isolation exercises to failure 01:01:37 Is there any value in manipulating proximity to failure over the course of a mesocycle? Sign-up for virtual nutrition counseling and personal training: Website: hammerawayfitness.com IG: https://www.instagram.com/hammerawayfitness/ Hammer Away Newsletter You can follow and support Lyle at: Website: https://bodyrecomposition.com/ Facebook Group: https://www.facebook.com/groups/810890695609053/ Support the show (https://www.patreon.com/themusclememoirs)