Maintaining an edge is one thing, but letting our edge in innovation dull has repercussions for the amount of food we can produce, the quality of life we live, and the potential for the next thing that will change the world. Are we keeping pace? Are the private sector, government, and the academy disrupting enough to innovate more or is there a stagnation that threatens continued development? Are certain parts of the world innovating better than other parts, who are the major catalyzers, and where does the intersection of technology and biology come into play? Carla Shatz, Dennis Charney, Margaret A. Hamburg, Corby Kummer, David Agus