With the rapid spread of Omicron and CDC guidelines changing on a near-daily basis, the pandemic can feel more confusing than ever. To help make sense of it all, we bring you this week’s episode two days ahead of schedule. Even in the face of a highly infectious variant, COVID vaccines still offer the best protection from severe illness and death, but 40% of the world’s population, mostly in low income countries, have yet to receive a first dose. With so many people unvaccinated, new variants will continue to emerge. So, what can be done to break vaccine gridlock and bring this pandemic to an end? On this week’s episode, Dr. Luciano Cesar Azevado, an ICU doctor in São Paulo, explains how Brazil went from being a COVID hotspot to a world leader in vaccinations. Then, Dr. Seth Berkley, CEO of GAVI, the Vaccine Alliance, talks with Ray Suarez about overcoming the challenges of vaccine distribution in hard to reach areas. Guests:  Dr. Luciano Cesar Azevado,  ICU physician and professor of critical care and emergency medicine, Sírio-Libanês Hospital in São Paulo, Brazil Dr. Seth Berkley, CEO, GAVI, The Vaccine Alliance Hosts: Philip Yun, CEO, World Affairs Ray Suarez, co-host, World Affairs