In this episode, Dennis M. Bier MD and Young Career Editor Kevin C. Klatt, PhD, RD speaks with Dylan McKay, PhD, Assistant Professor of Food and Human Nutritional Sciences at the University of Mannitoba and senior author of the recently published AJCN manuscript, “Genosets for APOE and CYP7A1-rs3808607 variants do not predict LDL cholesterol lowering upon intervention with plant sterols in a randomized, double-blind, placebo-controlled trial (https://doi.org/10.1093/ajcn/nqab378)”. In this episode, we dive into the potential to predict LDL-lowering through a nutraceutical intervention (i.e. plant phytosterols) using genetic variants and more broadly, discuss the emerging field of nutrigenetics and the need for rigor and application of gold-standard clinical trial designs in the field. Be sure to connect with us on twitter Dr. MacKay: @DylanMacKayPhD; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/ (https://nutrition.org/publications/).