While anxiety disorders are the most common mental health issue in the United States and are known to increase the risk of hypertension and cardiovascular disease, the links between anxiety, muscle sympathetic nerve activity and blood pressure have not been interrogated to date. Listen as host Dr. Megan Wenner (University of Delaware) interviews author Dr. Jeremy Bigalke (Montana State University) and expert Dr. Jody Greaney (The University of Texas at Arlington) about the latest research by Bigalke et al. Leveraging a large dataset of 88 young adults, the authors examined the relationship between anxiety, blood pressure and resting muscle sympathetic nerve activity using seated blood pressure measurements and the Spielberger State/Trait Anxiety Inventory, which denotes an individual’s propensity for anxiousness along a spectrum. After controlling for several key characteristics including age and sex, Bigalke and collaborators determined that there was a modest relationship between anxiety symptom severity and resting sympathetic outflow in young otherwise healthy adults. Do these changes in sympathetic regulation of blood pressure indicate a significantly increased long-term risk for cardiovascular comorbidities later in life? Our experts discuss this work in the context of the dramatic increase in patients diagnosed with anxiety and associated mental health disorders during the COVID pandemic, and delve into the consideration of sex as a biological variable in the prevalence of anxiety diagnoses among women compared with men. Why are multi-center collaborations critical to the future of research linking subjective psychological characteristics to physiological outcomes? Listen and find out.   Jeremy A. Bigalke, John J. Durocher, Ian M. Greenlund, Manda Keller-Ross, and Jason R. Carter Blood pressure and muscle sympathetic nerve activity are associated with trait anxiety in humans Am J Physiol Heart Circ Physiol, published February 17, 2023. DOI: 10.1152/ajpheart.00026.2023