Given that there appears to be variation in significant risk to the cardiovascular system following SARS-CoV2 infection with regard to age and sex, the latest study by Rouhana et al. provides a foundation for studying sex differences with a preclinical model of infection to the direct exposure to SARS-CoV-2 and the impact on the myocardium of ferrets. Listen as Associate Editor Dr. Keith Brunt (Dalhousie University) interviews authors Dr. Alyson Kelvin (University of Saskatchewan) and Dr. Glen Pyle (University of Guelph) along with expert Dr. Susan Cheng (Cedars-Sinai Smidt Heart Institute). The authors identified that phosphokinase expression, normally associated with cardiac stress remodeling, is distinct by time and sex effects. Additionally, the authors found that inflammatory patterns of macrophage markers showed inherent sex differences in immune responses at the level of the myocardium. Why are ferrets a such a useful preclinical model for understanding SARS-CoV2 infection? How do immune inflammatory responses differ by sex, timing, and age? As Dr. Brunt points out, “There is power in observation, collaboration, and when it comes to bugs and bodies…it’s physiology.” Read the paper, listen to this podcast, and find out more.   Sarah Rouhana, Kathy Jacyniak, Magen E. Francis, Darryl Falzarano, Alyson A. Kelvin, W. Glen Pyle Sex differences in the cardiac stress response following SARS-CoV-2 infection of ferrets Am J Physiol Heart Circ Physiol, published October 18, 2023. DOI: 10.1152/ajpheart.00101.2023