This episode centres around an article recently published in the Journal of Hepatology, presenting a new treatment algorithm positioned as an evolution of the BCLC system and aimed at addressing its limitations in the staging and therapy hierarchy for HCC. This discussion covers the implications of this fresh approach in the management of HCC patients, challenging the standard paradigm. Faculty Bruno Sangro (Moderator)Umberto Cillo (Faculty) Helen Reeves (Faculty)María Reig (Faculty)This EASL Studio is supported by AstraZeneca. EASL has received no input from AstraZeneca with regards to the content of this programme. Related episodes EASL Studio S5E13: Basics in decision-making for liver cancer treatmentEASL Studio from EASL Congress 2023: Highlights of the liver cancer research at EASL Congress 2023EASL Studio S4E16: Highlights from the EASL Liver Cancer Summit 2023EASL Studio S4 Special Edition 1: A new strategy for liver cancer screening: EASL Policy Statement on risk-based surveillanceEASL Studio S3E16: Liver cancer in 2022: Wrap-up & outlookEASL Studio S3E8: Transplanting patients with cancer – Is there a limit?EASL Studio S2E15: JHEP Live on the best animal model for HCC – Lost in translation?All EASL Studio Podcasts are available on EASL Campus.