Governments around the world failed to contain COVID-19, with more than 3.2 million deaths and counting. Even before the pandemic, the United States was questioning its commitments to global health, its leadership role, and a system of progressive prices for medicines whereby the rich pay more to subsidize access for the poor. The pandemic is far from over: cases are surging today in India, Brazil, Argentina, Colombia, Mexico, Russia, Turkey, Iran, Poland, Ukraine. Now, with the unprecedented pace of effective vaccine development and a new Administration in Washington, the US is called upon to lead again. Beth Cameron (US National Security Council) and Loyce Pace (US Department of Health and Human Services) discuss plans to restore US leadership for global health.