In the first pandemic of the datafied society, the disempowered were denied a voice in the heavily quantified mainstream narrative. Diego Cerna Aragón, Shyam Krishna, Silvia Masiero, Stefania Milan, Irene Poetranto, and Emiliano Treré invited participants to explore the pandemic from the perspective of communities and individuals at the margins in the Global South and beyond. It introduces the editorial project of the same title. Learn more: https://cyber.harvard.edu/events/covid-19-margins