Description
Professor Saltzman talks about cell communication, specifically ligand-receptor interactions that are important in maintaining homeostasis in the body. Different types of receptors and ligands, the nature of their interactions and ways to apply this into developing drugs are discussed (eg. Aldopa, Taximofen, beta-blockers). Next, Professor Saltzman talks about kinases, phosphatases, cyclic AMP and the mechanism of switching protein states. Three categories of cell communication signals are introduced: autocrine, paracrine, and endocrine. Finally, an example of cell communication using regulation/response to blood sugar level is presented.
In this final lecture, Professor Saltzman talks about artificial organs, with a stress on synthetic biomaterials. First, the body's responses (immunological and scar healing responses) to foreign materials are introduced. This leads to discussion of different types of polymer/plastic materials...
Published 10/12/09
Professor Saltzman uses cancer diagnosis and treatment as an example to demonstrate the some applications of biomedical engineering technologies and methods. Some issues involved in cancer treatment, such as tumor angiogenesis, radiation sensitivity, drug localization, and cancer stem cells are...
Published 10/12/09
In this lecture, Professor Saltzman continues his discussion of tissue engineering, and its role in facilitating healing, tissue regeneration, organ replacement, drug delivery and as model for studying human physiology. Specific examples from current research by scientists at Yale are used to...
Published 10/12/09