Please visit answersincme.com/DDC860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in pulmonology discusses the current guidelines and evidence on the use of sequential combination therapy in patients with pulmonary arterial hypertension (PAH). Upon completion of this activity, participants should be better able to: Review the current guideline recommendations on sequential combination therapy based on risk stratification in patients with pulmonary arterial hypertension (PAH); Discuss the biologic and clinical rationale for using guideline-recommended sequential combination therapy in patients with PAH; and Outline evidence-based, individualized strategies to optimize patient outcomes with sequential combination therapy in PAH.