The Food and Drug Administration has granted priority review to suzetrigine, a novel painkiller. It’s part of a new class of medications that could provide relief to those with chronic pain. The drugs target sodium channels on nerve cells, stopping pain signaling at the periphery. Journalist Marla Broadfoot explains the biology of aches and pains and the reasons it is so challenging to develop well-tolerated medications for pain. Recommended reading: New Painkiller Could Bring Relief to Millions—Without Addiction Risk  Ozempic Quiets Food Noise in the Brain—But How?  E-mail us at [email protected] if you have any questions, comments or ideas for stories we should cover! Discover something new every day: subscribe to Scientific American and sign up for Today in Science, our daily newsletter.  Science Quickly is produced by Rachel Feltman, Fonda Mwangi, Kelso Harper, Madison Goldberg and Jeff DelViscio. This episode was hosted by Rachel Feltman with guest Marla Broadfoot. Shayna Posses and Aaron Shattuck fact-check our show. The theme music was composed by Dominic Smith. Learn more about your ad choices. Visit megaphone.fm/adchoices