This week Dr. Drew is joined by comedian, Chris Distefano! Being both doctors, Dr. Drew inquires about Chris's choice to move on from physical therapy and pursue comedy full time. Chris also talks about his childhood and how 9/11 influenced his decision to become a comedian. Drew and Chris take a few live calls, covering subjects from testicles and poop to mental health and social media. Between the live calls and TikToks, Chris tells Drew about his transgender convict nanny, TT Jerry, and Drew educates Chris on taking testosterone. To wrap up the episode, Chris is introduced to the YMH Cool Guy, The King.