In this episode, Sam Ashoo, MD interviews Prayag Mehta, MD and Joshua Kern, MD – two of the authors of the June, 2022 EMP article on Procedural Sedation and Analgesia in the Emergency Department (https://www.ebmedicine.net/topics/emergency-procedures/emergency-medicine-procedural-sedation). Listen to the discussion to hear more about the emergency medicine approach to sedation in adults and pediatrics !Procedural Sedation and Analgesia in the Emergency DepartmentEMplify – June 2022Episode Outline:1.Procedural sedation and analgesia (PSA): terminology2.Levels of sedation* Minimal* Moderate* Deep* General anesthesia3.Prehospital care4.ED care: patient assessment* ASA class system* Complications* Equipment needed (Table 1)* Larson maneuver (Figure 2)5.Procedural technique* Current ACEP and AAP recommendations* Data for 1- or 2-physician sedation6.Preprocedural fasting* Do we even need to consider this in PSA?7.Capnography8.Oxygen supplementation9.Preprocedural opioids10.Preprocedural sedatives11.Anticholinergics12.Antiemetics13.Treatment (Table 2)* Fentanyl* Remifentanil* Midazolam* Nitrous oxide* Propofol* Ketamine* Ketofol* Etomidate14.Reversal agents* Naloxone* Flumazenil15.Special populations* Pediatrics* Pregnancy* Geriatrics16.Cutting edge* Dexmedetomidine