Announcements: The interactive Clinical Pathways (https://clinicalpathways.ebmedicine.net/) have launched and they are available for free! ___In this episode, Sam Ashoo, MD, and TR Eckler, MD, discuss the January 2023 Pediatric Emergency Medicine Practice article on the Responsible and Safe Use of Opioids in Children and Adolescents in the Emergency Department (https://www.ebmedicine.net/topics/pain-management/pediatric-emergency-medicine-responsible-use-of-opioids)DEA-X Waiver Repeal:* The Mainstreaming Addiction Act (https://www.congress.gov/bill/117th-congress/senate-bill/445)* The Medication Access and Training Expansion Act (MATE) (https://www.congress.gov/bill/117th-congress/house-bill/2067?q=%7B%22search%22%3A%5B%22MATE+Act+2021%22%2C%22MATE%22%2C%22Act%22%2C%222021%22%5D%7D&s=1&r=1)* FOAMed post (https://foamed.ebmedicine.net/general-emergency-medicine/news-updates/dea-x-waiver-ended/)Opioids in Children and Adolescents: Introduction* Epidemiology and Statistics Medication safety at homeEscalation of pain meds at homeNaloxone prescriptionsMedications in children* Codeine* Tramadol* NSAIDs* Local anesthetics and nerve blocks* Intranasal meds: Ketamine and fentanylOpioids and sedationRegional anesthesiaChronic pain