In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the August 2024 Emergency Medicine Practice article, Emergency Department Management of Patients With Sickle Cell DiseaseEpidemiology* Common Presentation of Sickle Cell Disease in the ED* Screening and Diagnosis Differences* Epidemiology: 200,000 ED Visits Annually, 85% for PainPathophysiology* Life Expectancy and Complications* Vado-Occlusive Crises and Pathophysiology* Sequestration Crisis in Sickle Cell Patients* Acute Chest Syndrome and PriapismClinical Management* Treatment Advocacy and Pain Management* Patient History and Examination Importance* Imaging Recommendations* Laboratory Studies and Findings* Emergency Department Care ProtocolsAdvanced Treatment Options* Intravenous (IV) Fluids Guideline* Management of Priapism* Role of Exchange Transfusion* Acute Chest Syndrome Details* Approach in Rural and Critical Access HospitalsSpecial Populations* Pregnant Patients with Sickle Cell Disease* Increased Risks and Complication Management