This week on Fat Science, we explore how popular digestive aids can interfere with your metabolism. Dr. Emily Cooper is back with co-hosts Andrea Taylor and Mark Wright. Dr. Cooper demystifies the roles of digestive enzymes and probiotics, offering a science-based approach to managing gut health. This episode sheds light on how diet impacts the microbiome plus the benefits and potential drawbacks of supplementation. Key Takeaways: Digestive enzymes help break down food, which may aid digestion, but they can backfire. Probiotics potentially improve gut microbiome health, but not all pro probiotics are alike. A varied diet rich in whole and fermented foods can naturally support gut health, often reducing the need for supplements. Caution against unnecessary food group elimination, particularly gluten, unless medically advised. Medical evaluation is crucial for identifying the root causes of gastrointestinal issues before resorting to supplements or restrictive diets. Long-term use of medications like PPIs for acid reflux has potential side effects, including disruption of the microbiome. Probiotics might help mitigate PPI-induced microbiome issues, but choosing the right one is key. Personal Stories & Practical Advice:  Andrea discusses her journey with acid reflux and surgical intervention, which resolved her need for medication. Mark shares his long-term experience with acid reducers, highlighting the importance of regular health checks and exploring alternative solutions. Resources from the episode: Connect with Dr. Emily Cooper on LinkedIn. Connect with Andrea Taylor on LinkedIn. Connect with Mark Wright on LinkedIn. Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay!) away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope.  Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice. If you have a show idea, feedback, or just want to connect, email [email protected].