A bike race injures several people, one of whom is left brain dead. Cristina and Izzie want to use his organs for organ donation, but they find the organ harvesting process an emotional one. Meanwhile, George deals with an over-flirtatious patient, and Meredith has to deal with Izzie and George moving in, Alex showing off, and keeping Derek at arm's length.

TW: Rape George and Izzie move in with Meredith. Burke works harder to become the next Chief and takes Webber's advice to start going the extra mile for patients. Derek helps a rape victim while Meredith carries around the rapist's penis. Alex Karev becomes one of Bailey's interns and shadows Cristina for the day.

In the pilot episode of Grey's Anatomy: Meredith Grey, Izzie Stevens, George O'Malley, Cristina Yang, and Alex Karev become interns at Seattle Grace Hospital. Meredith discovers that her one night stand was actually with one of her bosses and she and her new friends discover that being a surgeon isn't as easy or fun as they thought it would be.