In this episode of Hematopoiesis, Dr. Alexis Caulier has exciting conversations with three experts in the field about how early bench work on the genetic regulation of fetal hemoglobin led to the development of bedside gene therapies. Dr. David Nathan revisits the beneficial role of fetal hemoglobin to improve the clinical manifestations of hemoglobinopathies. Dr. Vijay Sankaran (@bloodgenes) highlights the great impact of studying gene regulatory networks in developing innovative gene therapies, and Dr. Courtney Fitzhugh (@CourtneyFitzhu1) emphasizes the importance and the specificities of clinical trials for innovative therapies.