This 14th episode of The Pain Beat is the second of a three-part series discussing the 2021 Nobel Prize in Physiology or Medicine – awarded to David Julius, University of California, San Francisco, USA and Ardem Patapoutian, Scripps Research, California, USA – for their work on molecules important for somatosensation (see PRF related interview here, PRF related news story here, and part one of this series here). In this episode, The Pain Beat spoke with Nobel Prize laureate Ardem Patapoutian and Bertrand Coste, Aix-Marseille University, France, to discuss their discovery of mechanically sensitive ion channels – Piezo1 and Piezo2. Podcast participants include: Ardem Patapoutian, PhD, Scripps Research, California, USA Bertrand Coste, PhD, Aix-Marseille University, France Tayler Sheahan, PhD, University of Pittsburgh, USA (Host)