K. Ray Chaudhuri, MD, DSc, Professor of Movement Disorders and Neurology at King’s College Hospital and King’s College London, UK, and Medical Director of the Parkinson Foundation International Centre of Excellence at King’s College, and Yazead Buhidma, a PhD student at the Wolfson Centre of Age-Related Diseases at King’s College London, discuss the problem of pain in Parkinson’s disease (PD), how researchers are studying PD pain in animals and what they are learning about its mechanisms.