This Pain Beat podcast discusses pain neuroimaging studies in people, with a focus on how studies of expectation and the placebo effect have advanced our understanding in this area. Podcast participants include: --Christian Büchel, MD, University Medical Center Hamburg-Eppendorf, Germany --Irene Tracey, DPhil, University of Oxford, UK --Tor Wager, PhD, Dartmouth College, Hanover, US --Howard Fields, MD, PhD, University of California San Francisco, US (moderator)