Join us on this week's episode as we delve into the complexities of osteoarthritis pain with Professor Nidhi Sofat. In this episode, we explore the sources of pain in osteoarthritis, from cartilage damage to synovitis and bone marrow lesions. Professor Sofat discusses groundbreaking research on the role of nerves and blood vessels in pain, the significance of bone and synovium in joint health, and the latest findings on gene expression and inflammation. We also cover the different types of pain - nociceptive, inflammatory, nociplastic, and neuropathic - and what this means for treatment. Whether you're a clinician, researcher, or someone affected by osteoarthritis, this episode offers valuable insights into understanding and managing this common yet complex condition. Nidhi Sofat is a Professor of Rheumatology at St George's, University of London, where she studies what causes pain and inflammation in diseases that affect muscles and joints. Her research takes a hands-on approach, bridging the gap between lab experiments and real-world medical applications.  Tune in for an enlightening conversation on the future of osteoarthritis research and discover how her team's innovative approaches may pave the way for future treatments in osteoarthritis. RESOURCES Journal article: Can we achieve pain stratification in musculoskeletal conditions? Implications for clinical practice Previous episodes: Why does my knee hurt with Dr. Jason McDougallWhere does osteoarthritis pain come from ? with Prof Anne-Marie Malfait CONNECT WITH US Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected] Hosted on Acast. See acast.com/privacy for more information.