The pandemic and the war in Ukraine have reshaped global geopolitics, trade, and security. How will these changes affect the relationship between the US and China, Europe, and the Global South? How will they impact US firms operating globally, and how might foreign leaders — and notably the Chinese leadership — respond? Recorded on February 16, 2023, this panel discussion featured a group of distinguished scholars addressing these questions, and the possible implications for the global multilateral order established in the second half of the 20th century.  The panel included Mariano-Florentino (Tino) Cuéllar, President of the Carnegie Endowment for International Peace; James Fearon, Theodore and Frances Geballe Professor in the Stanford School of Humanities and Sciences, a professor of Political Science, and Senior Fellow in the Freeman-Spogli Institute for International Studies; Pierre-Olivier Gourinchas, the Economic Counsellor and the Director of Research of the International Monetary Fund (who is on leave from UC Berkeley, where he is the S.K. and Angela Chan Professor of Global Management in the Department of Economics and at the Haas School of Business and Director of the Clausen Center for International Business and Policy; and Laura Tyson, Class of 1939 Professor of Economics and Business Administration and Distinguished Professor Emerita of Economics at UC Berkeley. The panel was moderaetd by John Zysman, Professor Emeritus at UC Berkeley and co-founder/co-director of the Berkeley Roundtable on the International Economy. The panel was held in Spieker Forum at the UC Berkeley Haas School of Business, and was co-sponsored by Social Science Matrix (https://matrix.berkeley.edu) and the Clausen Center for International Business & Policy (https://clausen.berkeley.edu/).