Professor Stuart Ralston presents Solving the Mysteries of Paget's Disease. Recent research has pinpointed genetic factors as major players in Paget's disease of the bone. Researchers have identified genes that are abnormal in people with the disease. This lecture will reveal what these genes are and how this knowledge can be harnessed to prevent complications of the disease occurring. This lecture is part of the Medical Detectives, a series of public lectures that show how keen detective work is still essential for 21st century doctors: http://www.ed.ac.uk/news/events/medical-detectives/ Recorded on 3 November 2011 in the Anatomy Lecture Theatre at the University of Edinburgh.