Summary In this episode of Melanoma Matters, hosts James Larkin and Sapna Patel welcome their first live guest, Toni Ribas. The conversation covers the evolution of melanoma treatments, the challenge of treatment resistance, and the importance of clinical trials. The episode emphasizes the need for continuous innovation and the importance of understanding the complexities of the immune system in cancer therapy. Takeaways Toni shares his journey in oncology, highlighting the importance of scientific exploration. Resistance to therapies remains a major challenge in melanoma treatment. Clinical trials are essential for understanding treatment efficacy and developing new strategies. Chasing complete responses in treatment is crucial for long-term patient outcomes. Patients should not be seen as failing treatments; rather, the focus should be on improving treatment strategies. Understanding the differences between mouse and human immune systems is vital for effective treatment development. Keywords melanoma, oncology, immunotherapy, targeted therapy, clinical trials, resistance, checkpoint inhibitors, cancer treatment, patient care, medical research Sound Bites "We need to do clinical experimentation." "We've democratized treatment of melanoma." Chapters 00:00 Introduction of Guest Toni Ribas 03:29 Toni Ribas' Journey in Oncology 05:44 A Brief History of Melanoma Treatment Before it was Cool 08:26 Understanding Resistance in Melanoma Therapy 11:25 The Role of Targeted Therapy and Immunotherapy 14:35 Clinical Trials and Lessons Learned 17:47 Chasing Complete Responses in Melanoma 20:18 The Future of Melanoma Treatment 22:49 Conclusion and Reflections