In 1874, John Nevins Andrews and his two children, Charles and Mary, travelled from the United States to Switzerland, the first missionaries sent by the Seventh-day Adventist Church. This episode explores the situation John found when he arrived in Switzerland, the difficulties he faced in confronting new cultures, his work to establish the first cross-cultural mission in Adventist history, and how both Mary and he came to die. It ends by considering Andrews's legacy.