Description
Gudrun talks with Changjing Zhuge. He is a guest in the group of Lennart Hilbert and works at the College of applied sciences and the Beijing Institute for Scientific and Engineering Computing (BISEC) at the Beijing University of Technology. He is a mathematician who is interested in system biology. In some cases he studies delay differential equations or systems of ordinary differential equations to characterize processes and interactions in the context of cancer research. The inbuilt delays originate e.g. from the modeling of hematopoietic stem cell populations. Hematopoietic stem cells give rise to other blood cells. Chemotherapy is frequently accompanied by unwished for side effects to the blood cell production due to the character of the drugs used. Often the production of white blood cells is hindered, which is called neutropenia. In an effort to circumvent that, together with chemotherapy, one treats the patient with granulocyte colony stimulating factor (G-CSF). To examine the effects of the typical periodic chemotherapy in generating neutropenia, and the corresponding response of this system to given to G-CSF Changjing and his colleagues studied relatively simple but physiologically realistic mathematical models for the hematopoietic stem cells. And these models are potential for modeling of other stem-like biosystems such as cancers. The delay in the system is related to the platelet maturation time and the differentiation rate from hematopoietic stem cells into the platelet cell. Changjing did his Bachelor in Mathematics at the Beijing University of Technology (2008) and continued with a PhD-program in Mathematics at the Zhou-Peiyuan Center for Applied Mathematics, Tsinghua University, China. He finished his PhD in 2014. During his time as PhD student he also worked for one year in Michael C Mackey's Lab at the Centre for Applied Mathematics in Bioscience and Medicine of the McGill University in Montreal (Canada).
Gudrun sprach im Januar 2024 mit zwei Studenten ihrer Vorlesung Mathematical Modelling and Simulation: Lukas Ullmer und Moritz Vogel. Sie hatten in ihrem Projekt Wahlmodelle ananlysiert. In dem Gespräch geht es darum, wie man hierfür mathematische Modelle findet, ob man Wahlsysteme fair gestalten...
Published 02/10/24
In dieser Folge geht es darum, wie Sebastian und Gudrun Mathematik an Hochschulen unterrichten und welche Rollen das Medium Podcast und konkret unser Podcast Modellansatz dabei spielen. Die Fragen stellte unsere Hörerin Franziska Blendin, die in der Folge 233 im Jahr 2020 über Ihr Fernstudium...
Published 10/03/23