Dr. Euan Ashley is a pioneer. In 2010, he led the team that conducted the first clinical interpretation of a human genome, and he holds the record for the world’s fastest genomic diagnosis. He even has a Guinness World Record to prove it. In this wide-ranging discussion, Dr. Ashley shares the stories behind these feats, his experiences applying artificial intelligence to genomics and to cardiology, and his views on whether and how AI will change medicine.