On this podcast episode, I discuss captopril pharmacology, kinetics, interactions, and much more! Captopril is an ACE Inhibitor. It can cause hyperkalemia, cough, and renal impairment. One of the notable issues with captopril is its relatively short half-life which requires it to be dose frequently throughout the day. Lithium is an important drug interaction and the use of captopril with this medication may increase concentrations and the chance for toxicity.