Zoledronic acid is a bisphosphonate that can be used to manage hypercalcemia of malignancy and osteoporosis. Glipizide is an anti-diabetes agent that is classified as a sulfonylurea. Weight gain and hypoglycemia and two big concerns with this agent. Lactulose is classified as a laxative but is more commonly used to reduce ammonia levels in hepatic encephalopathy. Rabeprazole is a PPI used to reduce gastric acid secretions and improve conditions such as GERD, peptic ulcer disease, and Barrett's esophagus. Methotrexate is classically grouped with oncology agents but is frequently used in autoimmune conditions like rheumatoid arthritis and Crohn's disease.