Adam Boulton and guests assess a stunning by-election defeat for the Conservatives in North Shropshire as the Liberal Democrats overturn a 23 thousand majority - with a 24% swing - and pile more pressure on Boris Johnson. They examine the impact of that result and what it means for the Prime Minister's leadership after a series of stories about sleaze and Downing Street parties. The panel also discuss the latest tensions between politicians and medical professionals over what to do about the Omicron variant of coronavirus and give their views on which leader should be most optimistic going into 2022. Joining Adam this week are the deputy political editor of the Daily Telegraph Lucy Fisher, the former press secretary to Paddy Ashdown Jo Phillips and Sky's chief political correspondent Jon Craig. #AllOutPolitics