In this episode of The ASHE Podcast, we dive into the significant advancements in clinical microbiology over the past decade as discussed in the paper "A Decade of Clinical Microbiology: Top 10 Advances in 10 Years: What Every Infection Preventionist and Antimicrobial Steward Should Know." Our expert panel, featuring Tulip A. Jhaveri, Zoe Freeman Weiss, Marisa L. Winkler, and Nicole D. Pecora, explores the categorization of tests within the typical clinician’s workflow, the evolution and impact of molecular diagnostics, and the future of home-based diagnostic testing. They also discuss the ongoing role of culture in microbiologic diagnosis, advancements in rapid susceptibility testing, and the challenges faced by clinical microbiology labs, including staffing shortages and FDA regulations. Tune in to understand how these advancements shape patient care and the future of clinical microbiology.