In the show’s first episode, host Vanda Felbab-Brown speaks with Dr. Jonathan Caulkins, a professor at Carnegie Mellon University, about the unique challenges that synthetic drugs, and particularly synthetic opioids, pose for policy. After laying out the history of drug use in the United States and the origins of the fentanyl epidemic, they discuss the pros and cons of a wide range of policies—from various law enforcement approaches to prevention, treatment, harm reduction, and prescribed safer supply. Show notes and transcript. Brought to you by the Brookings Podcast Network. Learn more at: Brookings.edu/KillingDrugs