In this episode, we delve into the critical topic of VTE prophylaxis in knee replacement surgeries. Special guest Dr. Atul Kamath from the Cleveland Clinic joins the discussion to share insights from a recent JBJS article advocating for low-dose aspirin as the safest and most effective prophylaxis for VTE after total knee arthroplasty across all patient risk profiles. Dr. Kamath, a seasoned orthopedic surgeon with an impressive academic and clinical background, provides an in-depth analysis of the study's methodology, results, and implications. The conversation touches on key points such as the rising trends in aspirin use, the comparative efficacy of different anticoagulants, and the cost benefits of using aspirin. Listeners will gain valuable knowledge on how this study could potentially shift clinical practices towards using aspirin for DVT prophylaxis, the importance of rapid recovery protocols, and the overall impact on patient outcomes. This episode promises to be a comprehensive guide for orthopedic professionals interested in the latest advancements in knee replacement surgery and DVT prevention. Follow us on (X) and Instagram @theskcpodcast, visit out SKC Podcast YouTube and Facebook pages, or email us at [email protected]