Evidence Based Perioperative Medicine (EBPOM)'s incredible World Congress in London continues and TopMedTalk is there bringing you exclusive interviews with delegates, guests and key opinion leaders. Here we have a much needed discussion regarding regulating artificial intelligence (AI) at the point of care, and the need for proper regulatory frameworks to ensure its safe and effective use. We stress the importance of clear policies and clinician training for AI implementation, highlighting the potential risks of misusing AI tools due to insufficient understanding of their outputs. How do we get transparency from AI manufacturers regarding the data sets used and the intended applications of their algorithms? Is there a need for independent verification bodies to assess the robustness of AI tools? The conversation concludes with a call for collaboration among clinicians, manufacturers, and regulators to harness the power of AI in healthcare while safeguarding patient outcomes, underscoring the exciting yet challenging future of AI in medicine. Presented by Andy Cumpstey and Joff Lacey with their guest Lee Fleisher, Emeritus Professor of Anesthesiology and Critical Care and Professor of Medicine at the University of Pennsylvania Perelman School of Medicine, Founder and Principal at Rubrum Advising, LLC, Senior Advisor of the Bipartisan Policy Center and FasterCures of the Milken Institute, Senior Fellow of the Leonard Davis Institute of Health Economics and Visiting Fellow of the Duke-Margolis Center. From July 2020-July 2023, he was the Chief Medical Officer and Director of the Center for Clinical Standards and Quality for the Centers for Medicare and Medicaid Services.