This conversation was recorded at The 7th Collaborative Clinical Trials in Anaesthesiology Conference, Prato, Italy. This piece focuses upon the TRACTION trial and the B-Free trial. The TRACTION trial is here: https://tractiontrials.org/ The B-Free trial is here: https://www.phri.ca/research/b-free/ Desiree Chappell and Andy Cumpstey speak with their guests Jessica Spence, Assistant Professor at McMaster University and the Principal Investigator of the B-Free Cluster Crossover Trial and Ryan Zarychanski Professor of internal medicine at the Max Rady College of Medicine, Hematologist, critical care physician and clinician-scientist at the University of Manitoba and CancerCare Manitoba.